Guy Umberto Poloni1, Enrico Marchioni2, Giovanni Magenes3, Gloria Castellazzi4
1Neuroradiology, Fondazione "Istituto Neurologico Casimiro Mondino" IRCCS, Pavia, PV, Italy; 2Neurology, Fondazione "Istituto Neurologico Casimiro Mondino" IRCCS, Pavia, PV, Italy; 3Bioengineering Department, Universita' degli Studi di Pavia, Pavia, 27100, Italy; 4Bioengineering Department, Universita' degli Studi di Pavia, Pavia, PV, Italy
DSC-MRI represents the widespread approach in neuroradiology for the PWI of cerebral tumors, limited in its efficacy by the breakdown of the BBB associated to high grade cerebral tumors. A multi-parametric approach was adopted to overcome technical limitations of the technique on 30 consecutive untreated patients affected by glioma of grades ranging from II to IV. A voxel-wise analysis of the perfusion T2* relaxivity curves, adopting a higher number of parameters than standard and an increasing level of sophistication of the pre-analysis, was performed demonstrating an improved sensitivity to cerebral hemodynamic alterations, particularly in regions where BBB injury occurs.