Abstract #0842

Evaluation of a New Multimodality Voxel-Based Imaging Biomarker for Therapeutic Response Assessment in GBM

Benjamin Lemasson¹, Thomas Chenevert¹, Theodore Lawrence², Christina Tsien², Pia Sundgren³, Charles Meyer¹,⁴, Larry Junck⁵, Jennifer Boes¹, Jean-Christophe Brisset¹, Stefanie Galbn², Timothy Johnson⁶, Alnawaz Rehemtulla¹, Brian Ross¹, Craig Galbn¹

¹Radiology, University of Michigan, Ann Arbor, MI, United States; ²Radiation Oncology, University of Michigan, Ann Arbor, MI, United States; ³Radiology, University of Michigan, Ann arbor, MI, United States; ⁴Biomedical, University of Michigan, Ann Arbor, MI, United States; ⁵Neurology, University of Michigan, Ann Arbor, MI, United States; ⁶Biostatistics, University of Michigan, Ann Arbor, MI, United States

The purpose was to evaluate the diagnostic performance of MRI based T1 and rCBV maps analyzed using a new multi-parametric response map (mPRM) base on a voxel-based analysis for early chemoradiation response prediction in patients diagnosed with high-grade gliomas. The percentage change, PRM and mPRM techniques using T1 and rCBVmap were used to assessed tumor response 1 and 3 weeks mid-treatment of 23 patients bearing glioma. mPRM_T1+/rCBV- significantly identified patients resistant irrespective of tumor volume delineation and the time point mid-treatment used. This new approach could become a powerful tool to analyze multiparametric and/or multimodal data.