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Abstract #0843

Measurement of 2-Hydroxyglutarate in Gliomas by Optimized 1H-MRS at 3.0 T

Changho Choi1, Sandeep Ganji1, Abhishek Banerjee1, Ivan Dimitrov1, 2, Ralph DeBerardinis1, Craig Malloy1, Bruce Mickey1, Robert Bachoo1, Elizabeth Maher1

1University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical Systems

We report noninvasive measurement of an oncometabolite, 2-hydroxuglutarate, in gliomas by TE-optimized 1H-MRS at 3T in vivo. The PRESS TE was optimized, with numerical and phantom analyses, as 97 ms for maximizing the 2HG multiplet at 2.25 ppm. This method was applied in 19 glioma patients, together with short-TE PRESS (35 ms). 2HG was detectable by both methods, but CRLB was smaller in the TE = 97 ms data than in the TE = 35 ms data. The TE = 97 ms method, with properly-calculated basis sets, may provide reliable detection of elevated 2HG compared to the short-TE method.