Measurement of 2-Hydroxyglutarate in Gliomas by Optimized 1H-MRS at 3.0 T

Changho Choi¹, Sandeep Ganji¹, Abhishek Banerjee¹, Ivan Dimitrov¹, ², Ralph DeBerardinis¹, Craig Malloy¹, Bruce Mickey¹, Robert Bachoo¹, Elizabeth Maher¹

We report noninvasive measurement of an oncometabolite, 2-hydroxuglutarate, in gliomas by TE-optimized 1H-MRS at 3T in vivo. The PRESS TE was optimized, with numerical and phantom analyses, as 97 ms for maximizing the 2HG multiplet at 2.25 ppm. This method was applied in 19 glioma patients, together with short-TE PRESS (35 ms). 2HG was detectable by both methods, but CRLB was smaller in the TE = 97 ms data than in the TE = 35 ms data. The TE = 97 ms method, with properly-calculated basis sets, may provide reliable detection of elevated 2HG compared to the short-TE method.