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Abstract #0844

Early Serial Functional Diffusion Mapping in Patients with Newly Diagnosed Glioblastoma During Combined Chemoradiation and Anti-Angiogenic Treatment

Pavlina Polaskova1, Marco C. Pinho1, Kyrre E. Emblem1, Jayashree Kalpathy-Cramer1, Dominique Jennings1, Elizabeth Gerstner2, A. Gregory Sorensen3, Alexander S.R. Guimaraes1, Tracy T. Batchelor2

1A.A. Martinos Center for Biomedical Imaging / Massachusetts General Hospital, Charlestown, MA, United States; 2Massachusetts General Hospital Cancer Center / Harvard Medical School, Boston, MA; 3Radiology, Harvard Medical School

Serial graded functional diffusion maps (fDM) provide a new insight into a glioblastoma patients response to therapy. It is challenging to choose one early time-point that would accurately predict the response to therapy, because the timing of significant changes (anti-vascular effect vs anti-tumor effect) is strongly dependent on the type of therapy. By looking at multiple time-points, our longitudinal assessment allows us to show early trends rather than one-time imaging changes. We found that continuous relative decrease in ADC at early time-points as shown by longitudinal FDM is associated with shorter survival.