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Abstract #0857

Diffusion Tensor & Kurtosis Metrics Along the Corticospinal Tract in Patients with Intracranial Tumors Show Complex WM Involvement

Danielle Van Westen1, Filip Szczepankiewicz2, 3, Markus Nilsson2, Freddy Sthlberg2, Jimmy Ltt1, Pia C. Sundgren3

1Center for Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden; 2Department of Medical Radiation Physics, Lund University, Lund, Sweden; 3Diagnostic Radiology, Lund University, Lund, Sweden

The usefulness of DTI- and DKI-metrics along the corticospinal tract (CST) for demonstrating white matter (WM) involvement in patients with intracranial tumors was evaluated by comparing estimates in patients and healthy controls. Edema, displacement, and infiltration of the CST significantly affected the metrics along the CST in the vicinity of intracranial tumor in individual patients. However, findings were complex and a larger material is required to assess the sensitivity of DTI- and DKI-metrics and possibly redefine the criteria for the each type of WM involvement; patterns described for visual assessment did not fully account for WM involvement.