Quantitative Magnetization Transfer in Human Glioma

Gerard Thompson¹, Sha Zhao¹, Goeff JM Parker¹, Alan Jackson¹

Quantitative magnetization transfer (qMT) has been used to study white matter diseases. qMT bound fraction (f) is considered to be a proxy of WM myelination. Since glial tumors arise in and invade white matter, changes in f may represent both affected white matter, and diagnostic information about the solid tumor component. Here we demonstrate that while f is not specific at distinguishing glioma grade or subtype, it is sensitive for the detection of solid tumor, and tumor and age-related white matter change in vivo. We also demonstrate that f can be derived accurately without the need for B1 correction at 3T.