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Abstract #0881

Striatal fMRI of Focal Ischemic Rat Brain

Yen-Yu Ian Shih1, Shiliang Huang1, Fang Du1, Timothy Q. Duong1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

The present study aimed to longitudinally investigate the striatum function in two groups of stroke rats V 20-min middle cerebral artery occlusion (MCAO) and 45-min MCAO. Our results demonstrated that the CBV fMRI reliably depicts striatal and cortical functions in stroke rats and 20- min MCAO showed better functional recovery. This technique has potential to longitudinally investigate the functional reorganization and evaluate treatment efficacy in the striatum of the same animal after stroke.