Abstract #0882

Restorative Strength of the Remodeled Vessels After Transient Focal Cerebral Ischemia in Rats: Evaluation with BOLD MRI

Chien-Hsiang Huang¹,², Chiao-Chi V. Chen², Tiing-Yee Siow², Fu-Shan Jaw¹, Chen Chang²

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; ²Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Vascular remodeling which restores oxygen and nutrient supply to the affected tissues improves the prognosis of stroke patient. Evaluating restorative strength of the remodeled vessels after ischemic insult provides important information to help guide the strategy of follow-up therapy. Dilatability and oxygenation ability of the vessels are the key characteristics that determine the restorative strength. This study aimed to explore the temporal changes of dilatability and oxygenation ability after transient focal cerebral ischemia in rats using BOLD MRI.