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Abstract #0891

Mapping of Oxygen by Imaging Lipids Relaxation Enhancement (MOBILE): Application in a Murine Stroke Model.

Julie Magat1, Caroline Vandeputte2, Uwe Himmelreich2, Bndicte F. Jordan1, Bernard Gallez1

1Biomedical Magnetic Resonance Group, Universit Catholique de Louvain, Brussels, Belgium; 2Biomedical Nuclear - Magnetic - Resonance Unit, Katholieke Universiteit Leuven, Leuven, Belgium

Imaging brain tissue oxygenation shortly after an acute ischemic stroke may help to aid in the selection of patients who may still benefit from thrombolytic treatment beyond conventional time-based guidelines. There is a critical need for methods able to monitor dynamically and noninvasively brain oxygenation. The aim of the current work was to implement the MOBILE technique, a method developed to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids by exploiting the higher solubility property of oxygen in lipids than in water (5), in a mouse stroke model.