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Abstract #0902

Underlying Tissue Pathologies of Focal Cerebral Ischemia in Rat Examined Using Diffusion MRI

Peng Sun1, Yong Wang1, Teng-Nan Lin2, Sheng-Kwei Song1

1Radiology, Washington University in St. Louis, Saint Louis, MO, United States; 22Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

DTI had been widely used to detect and characterize axonal injury and demyelination. However, diffusion parameters derived using DTI lose specificity and sensitivity with increasing pathological and anatomical complexity. Herein, diffusion basis spectrum imaging (DBSI) was employed to address DTI limitations resolving multiple-tensor water diffusion resulting from axon injury, demyelination, and inflammation in a rat stroke model of transient middle cerebral artery occlusion (MCAO). The current results suggest that DBSI may be used to more accurately reflect the underlying tissue destruction.