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Abstract #0903

Quantification of Cerebral Blood Volume Using Breath Hold in Rat

Seon Joo Kwon1, Woo Hyun Shim1, Bharat B. Biswal2, Young Ro Kim1

1Radiology, MGH, Charlestown, MA, United States; 2Radiology, New Jersey Medical School, Newark, NJ, United States

The typical CBV quantification strategy utilizes the systemic administration of MR contrast agents. In the current study, we propose to use breath hold (BH) and the associated tissue MRI signal changes to bypass the use of MR contrast agents and to enable the measurement repeatability. We compared the voxelwise CBV values acquired from the DSC (using Gd-DTPA) and BH methods in normal rat brains (n=6). The results from two techniques were significantly correlated, implicating that the BH technique can be used as a tool for quantifying CBV in replacement of traditional contrast agent methods.