Visualization of Immune Cell Dynamics in Mouse Brain with 11.7 T MRI

Yuki Mori¹, Yoshichika Yoshioka¹

Non-invasive monitoring of immune cells before/after neuroinflammatory conditions may lead to understand the mechanisms of brain injury and repair. We try to delineate the dynamics of immune cells in mouse brain using intravenous superparamagnetic iron oxide particles (SPIOs) enhancement. Intravenous SPIO-enhanced MRI has a great possibility for visualizing the recruitments and migrations of immune cells in mouse brain in vivo, even in the normal brain. Immune cells in the brain markedly increased in the inflammatory conditions. Our technique could contribute to establish the estimation method for treating brain injury and also maintenance in normal condition that target immune cells.