Cannabinod Treatment Induces Temporal Biomechanical Alterations in the Juvenile Rat Hippocampus

Simon Chatelin¹, Marie Humbert-Claude², Valrie Vilgrain¹, Bernard E. Van Beers¹, Zsolt Lenkei², Ralph Sinkus¹

This study shows for the first time a significant temporal alteration of young rat brain mechanical properties after cannabinod injection by in vivo MR-Elastography. This effect is relevant in fiber-rich regions and a modification of their axonal structures can be supposed. It would confirm that CB1R receptors may play an important role in the regulation of structural plasticity and neuronal remodeling in the postnatal brain with significant effects on brain stiffness.