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Abstract #0923

Rapid In-Vivo Imaging of Amyloid Plaques Using μ-MRI Gd-Staining and Ultrasound-Induced Blood Brain Barrier Opening

Mathieu David Santin1, 2, Thomas Debeir3, Sharon Lori Bridal4, Thomas Rooney3, Marc Dhenain1, 5

1Laboratoire des maladies neurodgnratives, URA 2210 CEA/CNRS, Fontenay-aux-Roses, France; 2Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Molle Epinire, Paris, France; 3Therapeutic Strategic Unit Aging, Sanofi-Aventis, Chilly-Mazarin, France; 4Laboratoire d'Imagerie Paramtrique, UMR 7623 CNRS/UPMC, Paris, France; 5MIRCen, CEA / I2BM, Fontenay-aux-Roses, France

This work presents a new imaging technique for in vivo detection of amyloid plaques, the main lesions of Alzheimer's disease. In transgenic mouse model of Alzheimer's disease, we combined techniques based on MRI Gd-staining method with transient opening of the blood brain barrier thanks to ultrasound (US). The images obtained with our new imaging protocol (US-Gd Staining) were compared with our previously published reference protocol consisting on an intracerebroventricular injection of an NMR contrast agent (ICV-Gd-Staining). Our new protocol allows in vivo amyloid plaque detection after an IV injection of an NMR contrast agent.