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Abstract #0924

Sequential Correlation of Relaxation Times with Motor Functions in an Experimental Model of Demyelination

Krithika Balasubramanian1, Anjali Chauhan2, Uma Sharma1, Senthil S. Kumaran1, Yogendra K. Gupta2, Naranamangalam R. Jagannathan1

1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Sequential monitoring of motor activity was carried out using four motor coordination tests in rats with lysophosphatidyl choline induced demyelination during different stages of the disease progression and regression. The results were correlated with T1 and T2 relaxation times measured at 4.7 T which increased during the progression of demyelination and subsequently decreased and reached normal values during remyelination. Activity on photoactometer, rotarod and grip strength showed negative correlation with T1 and T2 while foot fault test showed a strong positive correlation with the relaxation times. Thus MR parameters aid in understanding the pathophysiology of demyelination.