Abstract #0928

Axonal Degeneration in the APP/PS1 Mouse Model of Alzheimers Disease

Marianne Dorothea Keller¹, Nyoman Kurniawan², Kerstin Pannek¹, Stephen Edwards¹, Stephen Rose¹, Maree Smith¹, Elizabeth Coulson¹, Ian Brereton¹

¹The University of Queensland, Brisbane, Qld, Australia; ²The University of Queensland, Brisbane , Qld, Australia

The cholinergic hypothesis states that dysfunction of acetylcholine containing neurons cause the cognitive decline in Alzheimer's disease patients. This project used tractography in a transgenic mouse model (APP/PS1). The transgenic model develops a large Amyloid-β plaque load. We found significant changes due to axonal degeneration of cholinergic fibres that have their origin in the basal forebrain.