Abstract #0929

Kainic Acid Induced Seizures Spread from the Cortex to the Hippocampus After Traumatic Brain Injury

Joanna K. Huttunen¹, Antti M. Airaksinen¹, Artem Shatillo¹, Juha-Pekka Niskanen¹,², Asla Pitknen³,⁴, Olli Grhn¹

¹Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; ²Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; ³Dept. of Neurobiology, Epilepsy Research Laboratory, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; ⁴Department of Neurology, Kuopio University Hospital, Kuopio, Finland

The aim of the study was to investigate the origin of the kainic acid (KA) induced epileptic seizures after traumatic brain injury (TBI) utilizing simultaneous local field potential (LFP) and fMRI measurements. In all animals, KA induced seizures caused detectable responses in BOLD and LFP signals. The first epileptic seizure elicited BOLD response initially in the cortex before activating the hippocampus.