Meeting Banner
Abstract #0937

Regional Assessment of Magnetization Transfer Ratio in the Mouse Brain - Tracking Myelin Change in a Model of Toxic Demyelination.

Sveinung Fjr1, 2, Stig Wergeland1, 2, Lars B1, 2

1The Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; 2Department of Clinical Medicine, University of Bergen, Bergen, Norway

In multiple sclerosis and other demyelinating disorders of the central nervous system assessment of change in myelin content would be an important clinical tool. Magnetization Transfer Ratio (MTR) is a semiquantitative MR technique for detecting macromolecules, like myelin. In this study we have developed a guided semi-automatic method for detecting regional MTR change in the mouse brain. By comparing MTR change to histopathology we show that MTR can detect myelin change in several regions of the mouse brain, including deep gray matter.