Abstract #0938

Correlating Quantitative Magnetization Transfer (QMT) & Diffusion Tensor Imaging (DTI) with Myelin Histology in a Rat Model of Type III Multiple Sclerosis (MS) Lesions

Vaibhav Anil Janve¹,², Zhongliang Zu¹, Song-yi Yao³, Ke Li¹, Fang Lin Zhang³, Kevin Wilson¹, Xiawei Ou⁴, Mark Does¹,⁵, Subramaniam Sriram³, Daniel Gochberg¹,²

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; ²Department of Physics, Vanderbilt University, Nashville, TN, United States; ³Department of Neurology, Vanderbilt University School of medicine, Nashville, TN, United States; ⁴Department of Radiology, Arkansas Children's Hospital; ⁵Radiology and Radiological Sciences, Vanderbilt University

We present correlation of high-resolution 3D qMT and DTI matrices with reconstructed quantitative 3D myelin histology volume in a lipopolysacharide (LPS) mediated animal model of MS. We seek to develop an animal model system of type III oligodendrogliopathy which is seen in the relative absence of prominent lymphocytic infiltration. To our knowledge this is the first quantitative magnetic resonance myelin study of an animal model of Type III MS lesions. We find qMT measured apparent pool size ratio (PSR) and DTI measured radial diffusivity (RD) shows the strong correlation with histological measure of myelin content.