Peter S. LaViolette1, Andrew C. Discolo1, Kimberly A. Pechman2, Kathleen M. Schmainda, 13
1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 2Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 3Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States
We have developed a technique to precisely quantify and compare histology to MRI on a voxel-wise basis. We demonstrate its utility in a U87 rat brain tumor model, where we compare relative cerebral blood volume (rCBV) as measured with dynamic susceptibility contrast (DSC) MRI to ex vivo von Willebrand factor (vWF) expression.