Abstract #0942

Precise Correlation of Relative Cerebral Blood Volume & Von Willebrand Factor Stained Histology Using the HistToMRI Toolbox

Peter S. LaViolette¹, Andrew C. Discolo¹, Kimberly A. Pechman², Kathleen M. Schmainda,¹³

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; ²Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; ³Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

We have developed a technique to precisely quantify and compare histology to MRI on a voxel-wise basis. We demonstrate its utility in a U87 rat brain tumor model, where we compare relative cerebral blood volume (rCBV) as measured with dynamic susceptibility contrast (DSC) MRI to ex vivo von Willebrand factor (vWF) expression.