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Abstract #0943

MEMRI Reveals Neuronal Changes in Specific Hippocampal Substructures Following Sleep Deprivation

F.Y. Lee1, 2, I.Y. Zhou1, 2, S.J. Fan1, 2, A.Y. Ding1, 2, E.X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China

Sleep deprivation not only compromises alertness and cognitive performance, but also induces adverse effects in memory and emotional behaviors. In this study, we aim to employ high resolution MEMRI to probe in vivo neuronal changes following sleep deprivation. Significantly reduced Mn uptake was observed in the hippocampal region of the sleep deprived animals. In particular, the dentate gyrus exhibited the least Mn uptake, indicating its functional vulnerability to sleep deprivation.