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Abstract #0952

Manganese Enhancement in Posterior Piriform Cortex After Unilateral Bulbectomy in Neonatal SD Rats

F.Y. Lee1, 2, S.J. Fan1, 2, E.X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China

The olfactory system plays an important role for survival in rodents and shows robust plasticity after injury. Biological studies have observed regeneration of olfactory axons and synapse formation in the frontal cortex after neonatal unilateral olfactory bulb ablation (OBA). In this study, we aim to investigate how the transneuronal transportation of manganese after OBA would change with time. The results demonstrated that the enhancement in the ipsilateral pPir after OBA decreased at P28 as compared with that at P12, indicating recovery of olfactory function till this time was not very likely, although olfactory neurons would reconstituted within 30 days and form glomeruli-like structures.