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Abstract #0954

Manganese-Enhanced MRI of Rat Brain Using Manganese-Releasing Alginate Beads

ystein Olsen1, Kristine Skrdal2, Else-Marie Huuse2, Yrr Mrch3, Marte Thuen2, Marius Widere2

1Department of Radiography, Sr-Trndelag University College, Trondheim, Norway; 2Department of Circulation and Medical Imaging, University of Science and Technology, Trondheim, Norway; 3SINTEF, Trondheim, Norway

In this study temporal relaxation curves were extracted from T1 maps of rat brain tissue 6h, 24h, 3d, 6d and 10d after intraperitoneal injection of 1); manganese alginate beads (MnAlg) 40mg/kg, 2); MnAlg 120mg/kg and MnCl2 40mg/kg. Manganese releasing alginate beads provided good manganese-enhancement with reduction in T1 comparable to that of MnCl2 in the rat brain.