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Abstract #0959

Intracerebroventricular Infusion of Manganese Via Osmotic Pump

J. Keiko McCreary1, Albert R. Cross1, Gerlinde A.S. Metz1, L. Sorina Truica1

1Neuroscience, Canadian Center for Behavioural Neuroscience, Lethbridge, Alberta, Canada

In this study we investigated the use of an intra-cerebro-ventricular cannulation with the use of an osmotic pump to administer a continuous dose of MnCl2 and its effect on the tissue and behaviour. Here we compare a 7-day administration of Mn to a 28-day administration. In our study, we investigated histology, T1 mapping and behaviour.