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Abstract #0972

Characterization of Age-Related Changes in Human Brain Using Diffusion Kurtosis Imaging

Wenshu Qian1, Zhongping Zhang1, Ed X. Wu2, Pek-Lan Khong1, Mina Kim1

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China; 2Departments of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Diffusion kurtosis imaging (DKI), as an extension of conventional diffusion tensor imaging (DTI), was recently proposed to probe a non-Gaussian diffusion property. In this study, we aimed to characterize microstructural changes in a deep grey matter region using DKI at 3 Tesla clinical MRI system. Our results demonstrate that age-related changes in brain can be quantitatively assessed using DKI.