Abstract #0973

Abnromal Changes in Default Mode Network in Alzheimers Disease & Mild Cognitive Impairment Subjects Investigated by DTI & Resting-State FMRI

Xiaozhen Li¹, Tie-Qiang Li², Raffaella Crinelli¹, Hakan Fisher³, Anna Rieckmann⁴, Lars-Olof Wahlund¹

¹Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; ²Department of Medical Physics, Karolinska Institutet, Stockholm, Sweden; ³Department of Psychology, Stockholm University, Stockholm, Sweden; ⁴Aging Research Center, Karolinska Institutet, Stockholm, Sweden

In this study, we evaluated the abnormal changes of both microstructure and functional connectivity in Default Mode Network (DMN) in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) subjects using Diffusion Tensor Imaging (DTI) and resting-state function MRI (rs-fMRI).We found MCI shares features with AD. The structural and functional connectivity of DMN in both AD and MCI patients are abnormal.Our investigation is beneficial to further understanding of the structural and functional changes of AD in different stages.Moreover, it may contribute to an improved differential diagnosis in AD and MCI which are often clinically difficult to distinguish.