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Abstract #0973

Abnromal Changes in Default Mode Network in Alzheimers Disease & Mild Cognitive Impairment Subjects Investigated by DTI & Resting-State FMRI

Xiaozhen Li1, Tie-Qiang Li2, Raffaella Crinelli1, Hakan Fisher3, Anna Rieckmann4, Lars-Olof Wahlund1

1Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; 2Department of Medical Physics, Karolinska Institutet, Stockholm, Sweden; 3Department of Psychology, Stockholm University, Stockholm, Sweden; 4Aging Research Center, Karolinska Institutet, Stockholm, Sweden

In this study, we evaluated the abnormal changes of both microstructure and functional connectivity in Default Mode Network (DMN) in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) subjects using Diffusion Tensor Imaging (DTI) and resting-state function MRI (rs-fMRI).We found MCI shares features with AD. The structural and functional connectivity of DMN in both AD and MCI patients are abnormal.Our investigation is beneficial to further understanding of the structural and functional changes of AD in different stages.Moreover, it may contribute to an improved differential diagnosis in AD and MCI which are often clinically difficult to distinguish.