Altered Neuronal & Astroglial Metabolism in APP-PS1 Mouse Model of Alzheimers Disease

Vivek Tiwari¹, Pandichelvam Veeraiah¹, Anant Bahadur Patel¹

Alzheimer's disease is associated with dysfunction and deficit of neurotransmitters and synapses. Neurochemicals and cerebral metabolism was studied in 12 month old APP-PS1 mouse model of Alzheimer's disease. Level of Glutamate and NAA was found to be lower while inositol was significantly higher in APP-PS1 mouse. Glucose oxidation by glutamatergic and GABAergic neurons, and neurotransmitter cycling was found to be impaired significantly in APP-PS1 mice. In contrast, astroglial metabolism was found to be higher in APP-PS1 mice at cognitive impaired stage.