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Abstract #0997

In Vivo Detection of Alzheimer Disease in APP Transgenic Mice with T2-Mapping

Maximilian N. Voelker1, Stephan Roeskam2, Alexander M. Koenig1, Richard Dodel2, Johannes T. Heverhagen1

1Diagnostic Radiology, Philipps University, Marburg, Hessen, Germany; 2Department of Neurology, Philipps University, Marburg, Germany

Alzheimer disease can be detected by MRI in APP transgenic mice by T2-Mapping without the need for contrast agent or high resolution imaging. in vivo Alzheimer plaques imaging on transgenic mice is challenging because of small plaques size (20 - 70m), long measurement duration and limitation to ultra high fields (>7T). Indirect measurement of plaque load with T2-Mapping allows faster protocols and differentiation between APP- transgenic mice and wild type mice. Strong effects on T2 have been detected due to accumulation of iron in plaques.