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Abstract #1010

Temporal MRI Contrast Agent Enhancement Patterns Differ Between Bolus & Step-Down Infusion Arterial Input: A Possible Indicator of Edema Formation?

Robert A. Knight1, James R. Ewing1, Kishor Karki1, Joseph D. Fenstermacher2, Tavarekere N. Nagaraja2

1Neurology - NMR Research, Henry Ford Hospital, Detroit, MI, United States; 2Anesthesiology, Henry Ford Hospital, Detroit, MI, United States

The development of edema following cerebral ischemia and reperfusion is a critical factor in determining stroke severity and predicting outcome. As the ischemic injury evolves, the blood-brain barrier often becomes injured, allowing water and contrast agent to leak out of the damaged vessels. Thus, contrast enhanced MRI may represent a potential method for assessing post-stroke edema formation by tracking the interaction of the extravascular water molecules with the leaking MRCA.