Manus Donahue1, 2, Michael Ayad3, Ryan Moore1, Matthias van Osch4, Megan Strother1
1Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States; 2Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States; 3Neurosurgery, Cornell Medical Center, New York, NY, United States; 4Radiology, Leiden University, Leiden, Netherlands
The overall aim of this work is to develop and clinically implement a multi-modal 3.0T MRI protocol capable of quantitatively evaluating the relationship between tissue-level hemodynamic compensation mechanisms and stroke risk in patients with intracranial (IC) steno-occlusive disease. Conclusions demonstrate an inverse relationship (n=15) between baseline cerebral blood flow and angiographic opacification time (P=0.01), a positive correlation between hypercapnic-BOLD time-to-peak and opacification time (P=0.04), and a positive correlation between Modified Suzuki Score and BOLD hypercapnic-reactivity. These findings provide evidence that noninvasive MRI approaches provide complementary, yet noninvasive, information to angiography and clinical scores in IC stenosis patients.