Abstract #1015

Cerebral Blood Flow Measured by Pseudo-Continuous Arterial Spin Labelling: A Potential Marker for Outcome in Aneurysmal Subarachnoid Haemorrhage

Michael Kelly¹,², Matthew Rowland¹,², Thomas Okell¹, Michael Chappell³, Jon Westbrook², Peter Jezzard¹, Kyle Pattinson¹,²

¹FMRIB Centre, University of Oxford, Oxford, United Kingdom; ²Nuffield Dept of Anaesthetics, University of Oxford, Oxford, United Kingdom; ³Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

Delayed cerebral ischaemia (DCI) is the main cause of mortality following subarachnoid haemorrhage (SAH). Early brain injury following SAH can lead to reductions in cerebral blood flow (CBF) and may indicate DCI. We investigate the use of pseudo-continuous ASL (pCASL) to measure CBF in the acute phase post SAH. 6 patients were scanned on multiple occasions. A global decrease in CBF was detected on day 3 post SAH in one patient. This perfusion deficit was not detected by routine clinical assessment. The findings suggest measurement of CBF by pCASL can play a role in identifying patients at risk of DCI.