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Abstract #1064

High Spatial Resolution Cerebral Blood Flow Imaging of Rat Brain

Qiang Shen1, Bianca Gonzales Cerqueira1, Timothy Q. Duong1

1Reseach Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Cerebral blood flow (CBF) is an important physiological parameter. The majority of CBF studies in rat brain are ~500x500x2000 microns using single shot EPI. The goal of this study is to image CBF of the rat brain at 75μm x 56μm x 1mm. Excellent CBF contrasts were observed among different cortical and sub-cortical structures. By constructing a digital atlas, CBF of 146 structures and their tissue volume were obtained automatically. This study sets the stage for investigating CBF dysfunction for a wide range of neurological diseases.