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Abstract #1063

Vasculature Visualisation Using Blood Pool USPIO Contrast Agent Ferumoxytol in Humans

Deqiang Qiu1, Thomas Christen1, Wendy W. Ni1, Greg Zaharchuk1, Michael E. Moseley1

1Radiology, Stanford University, Stanford, CA, United States

Ultrasmall Superparamagnetic Iron Oxide (USPIO) is a strong T2* MR contrast agent that stays in the blood for long periods(~15hrs half-life). In this study, we explore the use of an FDA-approved USPIO compound ferumoxytol (labelled for treatment of iron-deficiency anemia) (AMAG Pharmaceuticals, Inc., Cambridge, MA) for enhanced visualisation of the vasculature. USPIO was demonstrated to have substantially improved detail of the smaller veins and vessels through a negative contrast. Tiny subcortical white matter lesions (unidentified bright objects [UBO]) appear relatively hyperintense structures in the USPIO-enhanced T2* images, suggesting low blood volume in UBOs. The use of persistant USPIO enhancement in the vasculature may aid in detection and characterization in many diseases.