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Abstract #1072

Enhanced Mylein-Related Contrast Across the Human Brain at 7T Using the Ratio of High Resolution T1 & T2* Weighted Images.

Federico De Martino1, 2, Junqian Xu1, Matthew Glasser3, David Van Essen3, Pierre-Francois van de Moortele1, Rainer Goebel4, Elia Formisano4, Kamil Ugurbil1, Essa Yacoub1

1Radiology, Center for Magnetic Resonance Research, Minneapolis, MN, United States; 2Cognitive Neuroscience, Maastricht Univeristy, Maastricht, Netherlands; 3Anatomy & Neurobiology, Washington University, St. Louis, MO, United States; 4Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

In Vivo MR anatomical contrast offers considerable promise for mapping cortical areas. Recently T1w and T2w images acquired at 3T were successfully combined to enhance myelin related anatomical contrast in vivo. At ultra-high fields (7 Tesla and above) anatomical contrast is enhanced and higher SNR permits higher spatial resolution images. we build on this idea of using ratio images to reduce intensity biases from the RF coil profile and show that mapping the ratio between T1 and T2* weighted images at 7T can reveal heavier myelination of several cortical areas in single subjects and high resolution.