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Abstract #1073

Quantitative Parametric Mapping and Tissue Sodium Concentration at 3T/4T

Zaheer Abbas1, Daniel P. Fiege1, Irene Neuner1, 2, Christian C. Mirkes, 13, Vincent Gras1, Sandro Romanzetti1, N. Jon Shah1, 4

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich, Jlich, Germany; 2Department of Psychiatry , Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; 3Max Planck Institute for Biological Cybernetics, Tbingen, Germany; 4JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Water content, or proton density (PD) and tissue sodium concentration (TSC) are tightly regulated in the human brain. A large number of diseases can be diagnosed and monitored observing these quantities. MRI protocols were set up to assess T1, T2*, PD and TSC quantitatively in vivo, and data from four healthy volunteers were acquired. Data were co-registered to the MNI brain and mean values for WM and GM structures were determined. Very good anatomical correspondence is achieved, despite combination of different imaging sequences.