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Abstract #1076

Repeated Fluoxetine Treatment During Adolescence Causes Regional Brain Atrophy in Adulthood: A Voxel-Based Morphormetry Study in Rat

Liqin Yang1, Hao Wu1, Fuchun Lin1, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

Fluoxetine (FLX) is the most popular prescription drugs for treatment of major depressive disorder in young populations. Recent studies have shown that chronic exposure to Selective serotonin reuptake inhibitors (SSRI), such as FLX, during adolescence or juvenile may cause neuroplastic effects on some brain regions. In this work, we constructed tissue probability maps (TPMs) of adult rat brain using high resolution volumetric T2-weighted image datasets, and used them to perform VBM analysis on the structural changes caused by repeated FLX treatment in adolescent rats.