Abstract #1080

Cerebral Atrophy in Streptozotocin-Induced Type 1 Diabetic Rats Revealed by Voxel-Based Morphometry

Mingming Huang¹, Lifeng Gao², Liqin Yang², Hao Lei³

¹State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences,, Wuhan, Hubei, China; ²State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences,, Wuhan, Hubei, China; ³State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, , Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences,, Wuhan, Hubei, China

Type 1 diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ). High resolution brain anatomical images were acquired with a RARE sequence. And this study was performed on a 7T scanner to monitor the brain anatomical changes induced by diabetes. From the RARE imagings, voxel-based morphometry analyses using 3 tissue classes probability altas can detect subtle volume changes in gray and white matters in diabetic rats at 4w after STZ injections, with gray matter atrophy in cortex, amygdala (Amy), caudate putamen (Cpu), hippocampus (Hip), thalamus, periaqueductal gray matter (PAG), and white matter atrophy in cingulum (cg), corpus callosum (cc), external capsule (ec), internal capsule (ic), cerebral peduncle (cp), optic tract (opt), fimbria (fi).