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Abstract #1081

Studying the Influence of the SeXY Chromosomes on Brain Development: A Mouse Model.

Jurgen Germann1, Armin Raznahan2, Frank Probst3, Jason P. Lerch1

1Mouse Imaging Centre, Sick Kids, Toronto, Ontario, Canada; 2Child Psychiatry, National Institute of Mental Health, Bethesda, MD, United States; 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States

Sex dimorphism and more general the role of sex chromosomes on brain development may provide crucial insight into neuropsychiatric disorders as nearly all of them have different ages of onset and gender bias in prevalence. Using the XO mouse model and whole brain high resolution imaging we found characteristic differences in brain morphology comparing mice with XO, XX< and XY genotypes providing an ideal model to investigate the role of sex chromosomes in brain development across various neurodevelopmental stages and genotypes.