In Vivo Cardiac 31P-MRS in a Mouse Model of Heart Failure

Adrianus J. Bakermans¹, Bastiaan J. van Nierop¹, Desiree Abdurrachim¹, Klaas Nicolay¹, Jeanine J. Prompers¹

3D Image-Selected in vivo Spectroscopy (ISIS) for non-invasive cardiac ³¹P-MRS was used to investigate the myocardial energy status in a thoracic aortic constriction (TAC) mouse model of heart failure. By maintaining a constant TR, signal contamination from tissue surrounding the heart was minimized. Left ventricular function and morphology were assessed using cine MRI.