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Abstract #1115

In Vivo Cardiac 31P-MRS in a Mouse Model of Heart Failure

Adrianus J. Bakermans1, Bastiaan J. van Nierop1, Desiree Abdurrachim1, Klaas Nicolay1, Jeanine J. Prompers1

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands

3D Image-Selected in vivo Spectroscopy (ISIS) for non-invasive cardiac 31P-MRS was used to investigate the myocardial energy status in a thoracic aortic constriction (TAC) mouse model of heart failure. By maintaining a constant TR, signal contamination from tissue surrounding the heart was minimized. Left ventricular function and morphology were assessed using cine MRI.