Johannes M. Froehlich1, 2, Nicole Graf3, Constantin von Weymarn1, Christoph A. Binkert1, Klaus Hergan4, Andreas Gutzeit1, 4
1Department of Radiology, Cantonal Hospital, Winterthur, Switzerland; 2Scientific Affairs, Guerbet, Zurich, Switzerland; 3Clinical Trials Center, Center for Clinical Research, University Hospital, Zurich, Switzerland; 4Department of Radiology, Paracelsus Medical University, Salzburg, Austria
Spasmolysis of the small bowel is crucial for high-quality imaging of the abdomen/pelvis. The aim of this prospective investigation was to evaluate the duration and effectiveness of aperistalsis achieved by glucagon(GLU/1mg) or hyoscine-N-butylbromide(HBB/40mg) administered intravenously(i.v.), intramuscularly(i.m.), or combined i.v./i.m.. Six volunteers underwent five separate MRI-examinations covering 60-90min. Onset of aperistalsis did not differ statistically in case of i.v. administration(65/85sec) ending after 2112.3min/23.314min, respectively. In contrast, spasmolysis of i.m. HBB and glucagon started significantly later(p=0.001) with 5.21.83min/11.610.2min. Aperistalsis lasted for 17.723.4min/28.226.9min with greater inter-individual differences(p=0.012). The combined scheme provides a rapid onset(65sec), prolonged effect(3110.7min) at the highest degree of aperistalsis.