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Abstract #1279

Towards Clinical MRI Measurements of Gastric Function and Emptying for a Standardised Liquid Nutrient Meal: Validation of Data Acquisition and Analysis.

Caroline L. Hoad1, Helen Parker2, Nicola Hudders2, Carolyn Costigan1, Eleanor F. Cox1, Luca Marciani2, Mark R. Fox2, Penelope A. Gowland1

1Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

This study develops a clinically applicable protocol to assess gastric function using MRI. A 400ml doped nutrient meal was ingested by ten healthy volunteers and their stomachs imaged using an optimised TrueFISP sequence. Total gastric (TGV) and liquid only volumes (LGV) were measured by 3 observers using an intensity based image segmentation algorithm. These volume data were then fitted to a complex model of gastric emptying to parameterize the secretion, relaxation and emptying of the stomach. Coefficients of variance (CV) were determined for the volumes and found to below 5% for all volumes greater than 100 ml.