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Abstract #1301

Pancreatic and Hepatic Fat Measurements Using 1H MRS and MDIXON with Flexible Echo Times.

Roshan Livingstone1, Paul Begovatz1, Sabine Link1, Bettina Nowotny1, Birgit Klueppelholz2, Guido Giani2, Juergen Bunke3, Michael Roden1, 4, Jong-Hee Hwang1

1Institute of Clinical Diabetology, German Diabetes Center, Dsseldorf, Germany; 2Institute for Biometry and Epidemiology, German Diabetes Center, Dsseldorf, Germany; 3Philips Healthcare, Hamburg, Germany; 4Department of Metabolic Diseases, University Clinics, Heinrich Heine University, Dsseldorf, Germany

1H-MRS is considered the gold standard for liver fat measurements, however, it is unclear whether H-1 MRS is more accurate for the pancreas than DIXON methods. A flexible 2-point mDIXON method (TE1/TE2 = 1.12/2.0 ms) was compared to 1H-MRS for fat fraction of the liver and pancreas in 19 volunteers. Values of hepatic fat fraction by mDIXON and 1H-MRS correlated well with each other (r = 0.96, p<0.00001), however, in the pancreas a correlation of (r=0.66, p<0.001) was found, which was probably attributed to differences in the amount and distribution of fat between the two organs.