Abstract #1301

Pancreatic and Hepatic Fat Measurements Using 1H MRS and MDIXON with Flexible Echo Times.

Roshan Livingstone¹, Paul Begovatz¹, Sabine Link¹, Bettina Nowotny¹, Birgit Klueppelholz², Guido Giani², Juergen Bunke³, Michael Roden¹,⁴, Jong-Hee Hwang¹

¹Institute of Clinical Diabetology, German Diabetes Center, Dsseldorf, Germany; ²Institute for Biometry and Epidemiology, German Diabetes Center, Dsseldorf, Germany; ³Philips Healthcare, Hamburg, Germany; ⁴Department of Metabolic Diseases, University Clinics, Heinrich Heine University, Dsseldorf, Germany

1H-MRS is considered the gold standard for liver fat measurements, however, it is unclear whether H-1 MRS is more accurate for the pancreas than DIXON methods. A flexible 2-point mDIXON method (TE1/TE2 = 1.12/2.0 ms) was compared to 1H-MRS for fat fraction of the liver and pancreas in 19 volunteers. Values of hepatic fat fraction by mDIXON and 1H-MRS correlated well with each other (r = 0.96, p<0.00001), however, in the pancreas a correlation of (r=0.66, p<0.001) was found, which was probably attributed to differences in the amount and distribution of fat between the two organs.