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Abstract #1302

Effect of Weight Loss on 1H MR-Observed Muscle, Liver and Abdominal Fat Distribution and Insulin Sensitivity

Suresh Anand Sadananthan1, 2, Eric Khoo Yin Hao3, Melvin K-S Leow1, 4, ChinMeng Khoo3, Lee Yung Seng1, 5, Peter Gluckman1, Tai E Shyong1, 3, S. Sendhil Velan1, 6

1Singapore Institute for Clinical Sciences, A*STAR, Singapore; 2Dept. of Obstetrics & Gynaecology, National University of Singapore, Singapore; 3Dept. of Medicine, National University of Singapore; 4Dept. of Endocrinology, Tan Tock Seng Hospital, Singapore; 5Dept. of Pediatrics, National University of Singapore; 6Singapore Bioimaging Consortium, A*STAR, Singapore

MRI and MRS allow for the investigation of changes in fat metabolism by exercise/dietary intervention in liver, muscle and abdominal fat (subcutaneous (SAT) and visceral (VAT)). In this study, we investigated the changes in fat distribution pre- and post-weight loss intervention in overweight Chinese men. The 16-week weight loss program consisted of three 90-min exercise sessions per week and a diet comprising of a caloric deficit of upto 1000 kcal. The results showed significant gain in fat depots post-weight loss except for IMCL. Further, the increase in SAT, VAT and %body-fat revealed significant correlations with the increase in insulin sensitivity.