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Abstract #1303

Introduction and Evaluation of Different Approaches for the (Semi-)quantitative Assessment of Renal Sodium Content with 23Na MR Imaging

Stefan Haneder1, Simon Konstandin2, John Morelli3, Lothar R. Schad2, Stefan O. Schoenberg1, Henrik J. Michaely1

1Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Baden-Wrttemberg, Germany; 2Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany; 3Scott and White Memorial Hospital and Clinic Texas A&M University Health Sciences Center, Temple, TX, United States

Two new approaches are introduced and evaluated for the (semi-)quantitative assessment of the renal sodium content with 23Na MR imaging before and after a water load. One approach used the cerebrospinal fluid as internal reference for the cortico-medullary 23Na gradient. The second approach quantified the cortico-medullary 23Na gradient with reduced numbers of slices. Both methods are compared to the gold standard quantification with complete data sets and external references. Both approaches showed non-significant differences compared to the gold standard and seem to be a feasible and faster alternative for potential clinical application.