Abstract #1363

Simultaneous Measurement of Fat Content and Phosphorous Compounds of Liver in Middle Aged to Elderly Healthy Subjects

Alessandra Laufs¹, Roshan Livingstone¹, Sabine Link¹, Bettina Nowotny¹, Birgit Klueppelholz², Guido Giani², Jrgen Bunke³, Michael Roden¹,⁴, Jong-Hee Hwang¹

¹Institute for Clinical Diabetology, German Diabetes Center, Dsseldorf, Germany; ²Institute for Biometry and Epidemiology, German Diabetes Center, Dsseldorf, Germany; ³Philips Healthcare, Hamburg, Germany; ⁴Department of Metabolic Diseases, University Clinics Dsseldorf, Heinrich Heine University, Dsseldorf, Germany

In order to evaluate relations between age, liver fat, and ATP in the liver in 51 healthy subjects over 40 years old, liver fat by ¹H MRS and ³¹P MRS of liver using 3D ISIS were obtained on a 3T scanner. As a result, the mean values of γ-ATP/Pi ratios and the liver fat content were 1.250.29 and 4.56%. ATP/Pi correlated with liver fat (r=0.29, p<0.05), and