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Abstract #1462

High Resolution Breast DWI to Evaluate the Tumor-Stromal Boundary in Patients Receiving Neoadjuvant Chemotherapy

Rebekah L. McLaughlin1, David C. Newitt2, Catherine Park3, Dorota Wisner2, Lisa J. Wilmes2, Evelyn Proctor2, Nola Hylton, 12

1The UC Berkeley - UCSF Graduate Program in Bioengineering, UC Berkeley & UCSF, San Francisco, CA, United States; 2Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 3Department of Radiation Oncology, UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA, United States

Using a high resolution DWI sequence for the breast, we investigated the changes in diffusion measurements relative to distance from the tumor boundary in patients receiving neoadjuvant treatment. In this study, we found that tumors and surrounding tissue had variable ADC patterns before and during neoadjuvant chemotherapy, suggesting that water mobility properties vary among tumors. Our early results suggest that a decrease in the change of tumor to stroma mean ADC values may identify tumors that will respond.