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Abstract #1463

Effect of Neoadjuvant Chemotherapy on the Fibroglandular Tissue Volume and Breast Density in the Contralateral Normal Breast: Evaluate at 3T MRI

Jeon-Hor Chen1, 2, Wei-Fan Pan2, Chih-Chen Kuo2, Julian Kao1, Li-Kuang Chen1, Jocelyn Lu1, Shadfar Bahri1, Rita S. Mehta3, Daniel H-E Chang1, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Center for Functional Onco-Imaging, Department of Radiological Science, University of California , Irvine, CA, United States; 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 3Department of Medicine, University of California Irvine, Orange, CA, United States

The results from our previous MRI monitoring study had shown that the reduction of breast density in patients receiving neoadjuvant chemotherapy (NAC) was majorly related to Doxorubicin and Cyclophosphamide (AC). The effect of taxane on the change of breast tissue is still not clear. 49 women receiving a new NAC protocol starting with 12 weeks of taxane with optional AC were studied for their 3D MR density change. The results show that NAC using Abraxane and Carboplatin also had similar effect on the reduction of FV and PD as did AC. The effect is age-related and duration-related. Since quantitative measures of FV and PD can be obtained on MRI, the reduction of these two parameters after NAC may potentially be used an imaging biomarker to correlate with future cancer risk occurring in the contralateral normal breast.