Differentiation of Benign from Malignant Non-Mass-Like-Enhancement in BRCA 1 Mutation Carriers Using Quantitative Kinetic Analysis

Alana R. Amarosa¹, Linda Moy¹, Amy Melsaether¹, Jason McKellop¹, Melanie Moccaldi¹, Jin Zhang¹, Sungheon Kim¹

The purpose of this study was to investigate the ability of quantitative kinetic analysis to identify malignant enhancing lesions on MRI in BRCA1 patients. In this retrospective study, we included 27 BRCA1 mutation carriers who underwent MRI guided biopsy. A linear principal component analysis (PCA) transformation was used to measure background parenchymal enhancement (BPE). Percent enhancement (PE) and early enhancement rate (S23) were measured in both lesion and BPE. PE and S23 for BPE were compared to those for malignant and benign lesions. Using our quantitative analysis, we found PE to be helpful in distinguishing between benign and malignant lesions.