Quantification of Prostate Metabolites at 3 T Using Water as the Internal Reference

Jan Weis¹, Francisco Ortiz-Nieto¹, Hkan Ahlstrm¹

Metabolite concentrations may be helpful in monitoring treatment efficacy, and relapse probability associated with prostate cancer. Single-voxel spectroscopy of the prostate at 3 T with surface coil was performed. Metabolite-to-unsuppressed water spectral intensity ratios of healthy volunteers and patients with biopsy-proven prostate cancer were determined with an LCModel. Mean normalized spectra, LCModel fits, and absolute concentrations of Cho, Cr, and Cit were computed for normal volunteers and cancer patients.