Abstract #1504

In-Vivo 3T and Ex-Vivo 7T Diffusion Tensor Imaging of Prostate Cancer - Correlation with Histology

Carlos Felipe Uribe Munoz¹,², Edward C. Jones³, Silvia D. Chang⁴, Larry Goldenberg⁵,⁶, Piotr Kozlowski²,⁵

¹Physics & Astronomy, University of British Columbia, Vancouver, British Columbia, Canada; ²MRI Research Centre, University of British Columbia, Vancouver, British Columbia, Canada; ³Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ⁴Radiology, University of British Columbia, Vancouver, British Columbia, Canada; ⁵Vancouver Prostate Centre, Vancouver, British Columbia, Canada; ⁶Urological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Diffusion Tensor Imaging (DTI) has been applied in prostate cancer diagnosis. It has been well accepted that water apparent diffusion coefficient (ADC) has a lower value in tumours than in healthy prostatic tissue, while fractional anisotropy (FA) has been reported to be higher, lower, and unchanged. Histology slices were registered with in-vivo and ex-vivo DTI images, and average values of ADC and FA were calculated for certain regions of interest. No significant differences in FA between normal peripheral zone and prostatic carcinoma were found suggesting that FA is not likely to contribute to diagnostic capabilities of DTI in prostate cancer.